Imbalanced Xovers: α-inflation? [General Statistics]
Hi ElMaestro,
Do you know that or do you assume it?
Yep. Mdme Potvin:
I was just interested in common 2,2,2 cross-overs.
❝ […] imbalance per se is not causing inflation of alpha in simple crossovers.
Do you know that or do you assume it?
❝ The phenomenon has not been studied or published for 2-stage designs, though.
Yep. Mdme Potvin:
“[…] each stage was assumed to be balanced with respect to sequence.”
Since I want to avoid troubles with regulators“The imbalanced case is outside the validated framework. The applicant should justify that the consumers’s risk is preserved in the actual study.”
I recommend my clients to randomize the second stage in such a way that imbalance in the first stage is counteracted (e.g., stage 1 TR|RT 10|12, ntotal 32, stage 2 TR|RT 6|4).❝ Did you mean to say something else?
I was just interested in common 2,2,2 cross-overs.
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Imbalanced Xovers: α-inflation? Helmut 2012-12-27 17:21 [General Statistics]
- Imbalanced Xovers: α-inflation? ElMaestro 2012-12-28 09:30
- Imbalanced Xovers: α-inflation?Helmut 2012-12-28 14:37
- please explain ElMaestro 2012-12-29 08:44
- I’ll try Helmut 2012-12-29 15:42
- please explain ElMaestro 2012-12-29 08:44
- Imbalanced Xovers: α-inflation?Helmut 2012-12-28 14:37
- Imbalanced Xovers: α-inflation? d_labes 2012-12-31 13:50
- One Mio sims of 2x2x2 in R in under 1 sec d_labes 2013-01-09 15:23
- Wow! Helmut 2013-01-09 16:10
- Unbalanced d_labes 2013-01-09 16:56
- α-inflation ≈ urban myth Helmut 2013-01-09 18:07
- Unbalanced d_labes 2013-01-09 16:56
- Wow! Helmut 2013-01-09 16:10
- Imbalanced Xovers: α-inflation? ElMaestro 2012-12-28 09:30