Bioequivalence and Bioavailability Forum • Sample size?

Sample size? [Power / Sample Size]

posted by The Outlaw Torn – Europe, 2012-11-22 11:55 (4501 d 13:15 ago) – Posting: # 9567
Views: 10,235

Goodmorning,

❝ Adding to what ElMaestro said my two cents: Maybe you can point out (in a polite way I’m not an expert in) that if one increases the sample size sooner or later any study will show a significant difference if the ratio is not exactly (!) 1. See this post. I don’t know your CV and sample size, but the sponsor cannot be blamed to have performed a study in “too” many subjects (I would avoid the term overpowered).

Just as a follow-up, would it be fair to twist a bit what you said and express it this way: "...that if one increases the sample size sooner or later any study will show a significant treatment difference if the ratio is not exactly one." Or is that too much wishful thinking?

The reason I'm asking is that the significant treatment effect is what seems to bother the assessor and not the fact that the ratio doesn't include unity (maybe both are linked statistically, but that's beyond my understanding).

Thank you.

Complete thread:

Significance The Outlaw Torn 2012-11-20 07:56 [Power / Sample Size]
- Significance ElMaestro 2012-11-20 08:17
  - Significance The Outlaw Torn 2012-11-20 08:55
    - Quality vs. Clinical ElMaestro 2012-11-20 09:04
- Sample size? Helmut 2012-11-20 20:10
  - Sample size? The Outlaw Torn 2012-11-21 07:52
  - Sample size?The Outlaw Torn 2012-11-22 10:55
    - Sample size, ratio, CV ↔ power Helmut 2012-11-22 13:35
      - Sample size, ratio, CV ↔ power The Outlaw Torn 2012-11-23 14:47
      - Sample size, ratio, CV ↔ power BEQool 2025-01-31 13:12
        
        TOST != treatment effect mittyri 2025-02-20 13:13
        Sample size, ratio, CV ↔ power zizou 2025-02-21 13:40
        
        Not vice versa mittyri 2025-02-22 21:08
        
        Not vice versa? zizou 2025-02-24 11:02
        
        Not vice versa? mittyri 2025-02-25 06:12
- Sample size calculation using Marzo and Balant method kumarnaidu 2013-01-31 07:48
  - Marzo / Balant formula d_labes 2013-01-31 10:05
    - Marzo / Balant formula kumarnaidu 2013-01-31 10:54
      - Marzo / Balant formula kumarnaidu 2013-02-04 05:48
        
        Marzo / Balant formula for parallel groups d_labes 2013-02-04 08:44