Bioequivalence and Bioavailability Forum • Sample size?

Sample size? [Power / Sample Size]

posted by The Outlaw Torn – Europe, 2012-11-21 08:52 (4497 d 23:41 ago) – Posting: # 9564
Views: 11,293

❝ Adding to what ElMaestro said my two cents: Maybe you can point out (in a polite way I’m not an expert in) that if one increases the sample size sooner or later any study will show a significant difference if the ratio is not exactly (!) 1. See this post. I don’t know your CV and sample size, but the sponsor cannot be blamed to have performed a study in “too” many subjects (I would avoid the term overpowered).

In turns out the client and assessor haven't mentioned anything specific about the CI not overlapping with unity. What the client focused on was the F-test for treatment effect (which, I guess, comes into play if the study was overpowered). I'll take a look at the assumptions in the sample size estimation and take it from there. Thanks for the lead.

Complete thread:

Significance The Outlaw Torn 2012-11-20 07:56 [Power / Sample Size]
- Significance ElMaestro 2012-11-20 08:17
  - Significance The Outlaw Torn 2012-11-20 08:55
    - Quality vs. Clinical ElMaestro 2012-11-20 09:04
- Sample size? Helmut 2012-11-20 20:10
  - Sample size?The Outlaw Torn 2012-11-21 07:52
  - Sample size? The Outlaw Torn 2012-11-22 10:55
    - Sample size, ratio, CV ↔ power Helmut 2012-11-22 13:35
      - Sample size, ratio, CV ↔ power The Outlaw Torn 2012-11-23 14:47
      - Sample size, ratio, CV ↔ power BEQool 2025-01-31 13:12
        
        TOST != treatment effect mittyri 2025-02-20 13:13
        Sample size, ratio, CV ↔ power zizou 2025-02-21 13:40
        
        Not vice versa mittyri 2025-02-22 21:08
        
        Not vice versa? zizou 2025-02-24 11:02
        
        Not vice versa? mittyri 2025-02-25 06:12
- Sample size calculation using Marzo and Balant method kumarnaidu 2013-01-31 07:48
  - Marzo / Balant formula d_labes 2013-01-31 10:05
    - Marzo / Balant formula kumarnaidu 2013-01-31 10:54
      - Marzo / Balant formula kumarnaidu 2013-02-04 05:48
        
        Marzo / Balant formula for parallel groups d_labes 2013-02-04 08:44