Quick Q for my clarification [Design Issues]
Hi ElMaestro!
Thank you for your quick reply with my attempt to answer the questions:
I was told that this design is standard for this kind of studies (one test and 2 references) and I think that straightforward doubling the sequence was intuitive with the aim to decrease the number of subjects (no power calculations available)
No idea regarding the intra-subject variability but this information may be important for planning upcoming studies
Scaling would be definitely an option if it turns out that the CV>30% (it's a NON-GXP study)
hope this helps
Martin
Thank you for your quick reply with my attempt to answer the questions:
I was told that this design is standard for this kind of studies (one test and 2 references) and I think that straightforward doubling the sequence was intuitive with the aim to decrease the number of subjects (no power calculations available)
No idea regarding the intra-subject variability but this information may be important for planning upcoming studies
Scaling would be definitely an option if it turns out that the CV>30% (it's a NON-GXP study)
hope this helps
Martin
Complete thread:
- Replicated cross over with fixed number of periods martin 2012-11-05 17:31 [Design Issues]
- Additional information martin 2012-11-06 11:50
- Quick Q for my clarification ElMaestro 2012-11-06 12:09
- Quick Q for my clarificationmartin 2012-11-06 12:29
- 5 periods ElMaestro 2012-11-06 12:43
- Latin Squares ↔ Williams’ designs Helmut 2012-11-06 14:07
- Latin Squares ↔ Williams’ designs Ben 2012-11-07 21:10
- Williams’ designs more reliable? d_labes 2012-11-08 08:29
- Williams’ designs more reliable? Ben 2012-11-09 18:20
- Williams’ designs more reliable? d_labes 2012-11-11 14:14
- Williams’ designs more reliable? Ben 2012-11-18 13:20
- Frequentists vs. Bayesians Helmut 2012-11-18 14:48
- Frequentists vs. Bayesians Ben 2012-11-18 15:28
- Frequentists vs. Bayesians Helmut 2012-11-18 14:48
- Williams’ designs more reliable? Ben 2012-11-18 13:20
- Williams’ designs more reliable? d_labes 2012-11-11 14:14
- Williams’ designs more reliable? Ben 2012-11-09 18:20
- Williams’ designs more reliable? d_labes 2012-11-08 08:29
- Latin Squares ↔ Williams’ designs Ben 2012-11-07 21:10
- Quick Q for my clarificationmartin 2012-11-06 12:29
- Quick Q for my clarification ElMaestro 2012-11-06 12:09
- Additional information martin 2012-11-06 11:50