Bioequivalence and Bioavailability Forum • power.inf()

power.inf() [BE/BA News]

posted by d_labes – Berlin, Germany, 2012-10-09 10:50 (5013 d 03:13 ago) – Posting: # 9351
Views: 14,890

Hi Gents!

❝ Of course conventional sample size estimation will not work. Maybe Detlew can consider adding sampleN.inf() to PowerTOST. :-D

Bug or a feature? :cool:

library(PowerTOST)

power.noninf(alpha=0.05, CV=0.298, margin=0.8, theta0=0.752, n=276)

# [1] 0.7998162

power.noninf(alpha=0.05, CV=0.298, margin=0.8, theta0=0.752, n=278)

# [1] 0.8023374

❝ But leaving power aside and assuming that we can exactly reproduce the ratio (75.2%) and CV (29.8%) of C_max it would need 227 (!) subjects in order to squeeze the upper CL below 80% ...

Code from this thread (replacing the calls to internal PowerTOST functions to PowerTOST:::func_to_call, f.i. PowerTOST:::.design.no(design)) gives me 228 :-D

—
Regards,

Detlew

Complete thread:

Bupropion ER Tablets Helmut 2012-10-05 15:59 [BE/BA News]
- Bupropion ER Tablets jag009 2012-10-05 22:30
- results, wording ElMaestro 2012-10-05 23:35
  - Null hypothesis, PowerTOST/sampleN.inf() Helmut 2012-10-06 01:14
    - Null hypothesis, PowerTOST/sampleN.inf() ElMaestro 2012-10-07 13:11
    - power.inf()d_labes 2012-10-09 08:50
      - power.inf() Helmut 2012-10-09 13:38
        
        power.inf() d_labes 2012-10-09 15:58
        
        power.inf() Helmut 2012-10-09 19:51