Bioequivalence and Bioavailability Forum

MSE calculation from CI of 4x4x4 study [General Sta­tis­tics]

posted by d_labes  – Berlin, Germany, 2012-09-25 12:40 (4611 d 10:06 ago) – Posting: # 9248
Views: 11,410

Hi John,

❝ So for a 4-way (4 period, 4 sequence,4 treatments) crossover or 4x4x4:

❝ df = 3*(n1+n2+n3+n4)-6? with ni = number of subjects per sequence.

Correct. But don't forget to set the design constant b_k(ni)=1/8

❝ What would the formula be if you go even higher? 5-way?

The overall formula remains as written above.
But you have to figure out the df and bk(ni). Not enough spare time at me to do that for you .

Complete thread:

• MSE calculation jag009 2012-09-13 17:39 [General Sta­tis­tics] 
  • MSE calculation from CI of 3x3x3 study d_labes 2012-09-14 09:43
    • Oops! Helmut 2012-09-14 14:31
      • Oops? One or two-tailed? ElMaestro 2012-09-14 15:48
        • One or two-tailed? d_labes 2012-09-17 09:57
          • One or two-tailed? Astea 2015-02-05 01:20
            • Sample size, alpha, beta, beta/2 and that all d_labes 2015-02-05 09:31
              • Sample size, alpha, beta, beta/2 and that all Astea 2015-02-07 12:53
                • Sample size, alpha, beta, beta/2 and that all d_labes 2015-02-07 16:22
    • MSE calculation from CI of 3x3x3 study jag009 2012-09-24 20:12
      • MSE calculation from CI of 4x4x4 studyd_labes 2012-09-25 10:40
        • MSE calculation from CI of 4x4x4 study jag009 2012-09-25 14:59
      • MSE calculation from CI of 3x3x3 study ElMaestro 2015-02-05 12:57