Bioequivalence and Bioavailability Forum

Hi Risherd,

❝ I found out that WinNonlin estimate the F-value like this

❝ Sequence effect

❝ F-value = MS sequence / MS sequence*volunteer

❝

❝ Using Bear data and applying the previous formula I obtain the same result of WinNonlin

❝ F-value = 0.4585/0.105425 = 4.34.

Quick note: Looks to me like Bear in your case is diving the Seq MS with the residual coming from a model with just Seq? I am not sure how this value of 0.0566 entered the scene. The current standard, as far as I know, is to divide with the subject MS just like you describe (MS sequence*volunteer is the same as MS volunteer*sequence, which is the same as MS subject in sequence, which is the same as MS sequence in subject, although the latter is a cosmic mindf%&#er to interpret).