Sequence effect bear vs WinNonlin opposite results [Software]
Hello everybody!
I did a software validation of WinNonlin with R program and in the ANOVA analysis I got the following results for the sequence effect:
AUC0-t.
-BEAR
Tests of Hypothesis using the Type III MS for SUBJECT(SEQUENCE) as an error term
Sequence Effect: F-value = 8.4; Pr>F=0.00958
-WINNONLIN
Sequence Effect: F-value = 4.593; P_value = 0.07053
As you can see according to bear there is a sequence effect for AUCo-t while in WinNonlin it's not. This same situation happen with AUC0-Inf.
However, the results for NCA, period, drug, seq(subj) effect, Confidence Intervals are exactly the same in both programs. So, why only the sequence effect is different?
Thank you for your answer on understanding this situation.
Risherd.
I did a software validation of WinNonlin with R program and in the ANOVA analysis I got the following results for the sequence effect:
AUC0-t.
-BEAR
Tests of Hypothesis using the Type III MS for SUBJECT(SEQUENCE) as an error term
Sequence Effect: F-value = 8.4; Pr>F=0.00958
-WINNONLIN
Sequence Effect: F-value = 4.593; P_value = 0.07053
As you can see according to bear there is a sequence effect for AUCo-t while in WinNonlin it's not. This same situation happen with AUC0-Inf.
However, the results for NCA, period, drug, seq(subj) effect, Confidence Intervals are exactly the same in both programs. So, why only the sequence effect is different?
Thank you for your answer on understanding this situation.
Risherd.
Complete thread:
- Sequence effect bear vs WinNonlin opposite resultsRisherd 2012-08-27 20:39 [Software]
- Sequence effect bear vs WinNonlin opposite results yjlee168 2012-08-27 21:35
- Sequence effect bear vs WinNonlin opposite results ElMaestro 2012-08-27 22:37
- Sequence effect bear vs WinNonlin opposite results yjlee168 2012-08-29 02:53
- SAS Type I/III ↔ WinNonlin partial/sequential tests Helmut 2012-08-28 14:39
- Sequence effect bear vs WinNonlin opposite results ElMaestro 2012-08-28 19:13
- Sequence effect bear vs WinNonlin opposite results Risherd 2012-08-29 18:09
- Division by 0.0566? ElMaestro 2012-08-29 19:42
- Related to AUC Parameter… Tushar.g 2012-09-11 13:29
- Sequence effect bear vs WinNonlin opposite results Risherd 2012-08-29 18:09