how to use Loo Riegelman method and deconvolution [Dissolution / BCS / IVIVC]

posted by vjkumar – India, 2012-08-23 14:03 (4320 d 10:55 ago) – Posting: # 9096
Views: 6,091

(edited by Ohlbe on 2012-08-23 14:22)

Hi Laili,
sorry for a late response but i think for loo-riegelman deconvolution you should have a look at book of Gibaldi and Perrier pharmacokinetics 2nd edition page no. 155- 162

provided parameters like
K12;
K21;
Ke or K10;

you can calculate by using following equations:-
K21=((A1*b)+(B1*a))/a+b;
Ke= (a*b)/K21;
K12= a+b-K21-Ke;

Hope it will work for you
vijay


Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe]

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