Bioequivalence and Bioavailability Forum • Eyeball-PK

Eyeball-PK [NCA / SHAM]

posted by hiren379 – India, 2012-07-11 17:28 (4664 d 13:13 ago) – Posting: # 8932
Views: 24,202

Dear HS,
Thanks for your inputs

❝ There is no absorption if the drug is administered directly to the central compartment. In rare cases you may notice an increase of concentrations after the end of infusion. This may occur if the drug precipitates in the vein. Then you have a true absorption process (actually dissolution). Dissolution may take place either in the vein itself or (downstream) in the lungs.

Ok, I need little bit further clarification and for that please concider these properties of a drug (BE study...NCA used)

Drug is a pure solution and nothing like precipitation and all. I mean pure solution form
Instantaneous distribution happens in your central compartment.
No compartmental specific distribution or in and out from any compartment

So if 1, 2 and 3 are correct. Cant we concider that elimination phase is only working phase as soon as infusion is over?

And if yes since you are knowing from what time the elimination phase has started it would be a bias if you are selecting 3 or 4 points from bottom of the curve to find Kel irrespective you are going for R2 or mannual.

One has to select all the time point in the elimination phase characterization.

In extra-vascular since we are unable to differentiate from where the elimination starts we start from bottom of curve and go up.

❝ ❝ ❝ Please avoid SMS spelling in your messages on this forum.

❝ ❝ sorry as I am new to this forum

❝

❝ … still a newbie after >2½ years? ;-)

I am not still an addict to this forum. But I am sure I will be 100%

Complete thread:

Methods for calculation of half lives d_labes 2008-02-01 14:58 [NCA / SHAM]
- Methods for calculation of half lives Helmut 2008-02-01 16:59
  - Methods for calculation of half lives Ohlbe 2008-02-02 23:00
    - Minimum AIC?! Helmut 2008-02-03 13:49
      - G (Kinetica) = R²adj (WinNonlin) Helmut 2008-02-04 01:12
  - Methods for calculation of half lives d_labes 2008-02-04 16:43
    - MAIC and beyond... Helmut 2008-02-04 17:49
- TTT method Helmut 2008-05-10 13:56
  - TTT method d_labes 2008-05-16 09:12
    - TTT method Helmut 2008-05-16 17:21
      - TTT method d_labes 2008-05-23 15:43
        
        TTT method hiren379 2012-07-11 11:11
        
        TTT method Ohlbe 2012-07-11 11:37
        
        TTT method hiren379 2012-07-11 11:44
        
        TTT method Ohlbe 2012-07-11 12:16
        
        TTT method hiren379 2012-07-11 12:53
        
        Eyeball-PK Helmut 2012-07-11 14:37
        
        Eyeball-PKhiren379 2012-07-11 15:28
        
        Eyeball-PK Helmut 2012-07-11 15:47
        
        Eyeball-PK hiren379 2012-07-11 16:24