Bioequivalence and Bioavailability Forum • TTT method

TTT method [NCA / SHAM]

posted by Ohlbe – France, 2012-07-11 14:16 (4725 d 00:43 ago) – Posting: # 8929
Views: 25,122

Dear Hiren,

❝ And if u are assuming...

Please avoid SMS spelling in your messages on this forum.

❝ Thanks but will the same work for Non compartmental model also?

Let me replace multicompartmental with multiphasic, then ?

❝ And if you are so worried about including the time of distribution then the postulate of instantaneous distribution is violated

Why make such a postulate ? Look at the PK profiles first.

❝ And if u are assuming instantaneous distribution then one must take all time points after completion of infusion to avoid bias created by statistics of R2

1. F*** R2
2. I don't assume instantaneous distribution or monophasic elimination without looking at the PK profiles for each subject.
(Also look at Helmut's first message in this same thread).

Regards
Ohlbe

—
Regards
Ohlbe

Complete thread:

Methods for calculation of half lives d_labes 2008-02-01 14:58 [NCA / SHAM]
- Methods for calculation of half lives Helmut 2008-02-01 16:59
  - Methods for calculation of half lives Ohlbe 2008-02-02 23:00
    - Minimum AIC?! Helmut 2008-02-03 13:49
      - G (Kinetica) = R²adj (WinNonlin) Helmut 2008-02-04 01:12
  - Methods for calculation of half lives d_labes 2008-02-04 16:43
    - MAIC and beyond... Helmut 2008-02-04 17:49
- TTT method Helmut 2008-05-10 13:56
  - TTT method d_labes 2008-05-16 09:12
    - TTT method Helmut 2008-05-16 17:21
      - TTT method d_labes 2008-05-23 15:43
        
        TTT method hiren379 2012-07-11 11:11
        
        TTT method Ohlbe 2012-07-11 11:37
        
        TTT method hiren379 2012-07-11 11:44
        
        TTT methodOhlbe 2012-07-11 12:16
        
        TTT method hiren379 2012-07-11 12:53
        
        Eyeball-PK Helmut 2012-07-11 14:37
        
        Eyeball-PK hiren379 2012-07-11 15:28
        
        Eyeball-PK Helmut 2012-07-11 15:47
        
        Eyeball-PK hiren379 2012-07-11 16:24