BE studies with Apple sauce [Study Per­for­mance]

posted by Helmut Homepage – Vienna, Austria, 2012-07-10 20:07 (5101 d 00:20 ago) – Posting: # 8919
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Hi John!

❝ Is it possible to fail a BE study on applesauce give that the fasting BE (non-applesauce) study is perfectly bioequivalent. […] Fed study is BE was well.


Would be a surprise. pH of apple sauce is ~3.2–3.5; acidic but well above gastric conditions. Can’t imagine that the coating would be affected in the short time the pellets are sprinkled. ;-)

❝ Just curious if the capsule shell itself would have an effect.


Very (very) unlikely, IMHO.

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