Bioequivalence and Bioavailability Forum • Dancing with the dice

Dancing with the dice [Regulatives / Guidelines]

posted by d_labes – Berlin, Germany, 2012-06-18 17:38 (4747 d 18:00 ago) – Posting: # 8774
Views: 13,458

Hi Mon Captain, dear Helmut,

❝ ❝ while (sum(x) != 0) x <- sign(rnorm(size))

❝

❝ ... It completely permutes equal numbers of TR and RT (or -1's and 1's).

Not really. It rolls the 'binary dice' 24 times again and again until the vector of +1's and -1's has the same number of both entries (is 'balanced').

Thus while being programmed along an "incredibly elegant way of achieving a lot with minimum coding" not so very effective concerning computational time if one considers what is intended (have seen more than 20 loop passes in a short experimentation).

—
Regards,

Detlew

Complete thread:

USFDA requirement for randomization Ravi 2012-06-15 13:39 [Regulatives / Guidelines]
- randomization: validation Helmut 2012-06-15 17:39
  - randomization: runs test? validation? d_labes 2012-06-16 13:10
    - randomization: runs test? validation? Helmut 2012-06-16 14:00
      - probability nearly zero? d_labes 2012-06-16 16:11
        
        probability nearly zero! Helmut 2012-06-16 17:08
        
        R-package randomizeBE d_labes 2012-07-06 09:54
        
        R-package randomizeBE Helmut 2012-07-06 12:51
  - randomization: validation ElMaestro 2012-06-16 13:31
    - randomization: runs test Helmut 2012-06-16 14:42
      - randomization: runs test ElMaestro 2012-06-16 14:48
        
        randomization: runs test Helmut 2012-06-16 15:10
      - very cool coding style ElMaestro 2012-06-16 19:12
        
        Better a good steal than a bad reinvention Helmut 2012-06-17 13:22
        
        Better a good steal than a bad reinvention ElMaestro 2012-06-17 19:58
        
        Sorry! Helmut 2012-06-18 13:26
        
        Sorry! ElMaestro 2012-06-18 15:19
        
        Dancing with the diced_labes 2012-06-18 15:38
        
        Silly's randomization 2x2 xover d_labes 2012-06-18 16:30
        
        Silly's randomization 2x2 xover Helmut 2012-06-18 17:14
        
        Clumsy code Helmut 2012-06-18 17:42
        
        Clumsy code ElMaestro 2012-06-18 18:01
        
        Speed kills Helmut 2012-06-18 18:56
        
        Speed kills jag009 2012-09-17 21:46