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RegisterSorry! [Regulatives / Guidelines]
Hi HS,
I had this discussion before with a client. The thing is, after a single pass through all the subjects, the sequence designation is as random as it wil be after 123 passes etc.
But I think this is difficult to somehow grasp out there. Key to realising it is that for each swap, there is exactly 50% chance that the subject will remain his/her firstly designated sequence, and 50% chance that it will be the other. After the full pass through all the subjects they are therefore fully randomised. But due to my lack of communication skills I failed to get that message across properly. So, it ended with a completely meaningless discussion like:
EM: "Would you like me to randomise the sequence XYZ times?"
Client: "Yes, please. They need to be fully randomised."
… and then I just smiled to my client and banged my head into the wall a couple times and took a handful of Schützomycin. It helped a little. They let me out of the loony bin after just 5 months.
❝ Sorry, didn’t realize that ‘silly’ has to be taken literally. Why did you include this loop at all? To slow down the algo?
I had this discussion before with a client. The thing is, after a single pass through all the subjects, the sequence designation is as random as it wil be after 123 passes etc.
But I think this is difficult to somehow grasp out there. Key to realising it is that for each swap, there is exactly 50% chance that the subject will remain his/her firstly designated sequence, and 50% chance that it will be the other. After the full pass through all the subjects they are therefore fully randomised. But due to my lack of communication skills I failed to get that message across properly. So, it ended with a completely meaningless discussion like:
EM: "Would you like me to randomise the sequence XYZ times?"
Client: "Yes, please. They need to be fully randomised."
… and then I just smiled to my client and banged my head into the wall a couple times and took a handful of Schützomycin. It helped a little. They let me out of the loony bin after just 5 months.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- USFDA requirement for randomization Ravi 2012-06-15 13:39 [Regulatives / Guidelines]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- randomization: validation Helmut 2012-06-15 17:39
- randomization: runs test? validation? d_labes 2012-06-16 13:10
- randomization: runs test? validation? Helmut 2012-06-16 14:00
- probability nearly zero? d_labes 2012-06-16 16:11
- probability nearly zero! Helmut 2012-06-16 17:08
- R-package randomizeBE d_labes 2012-07-06 09:54
- R-package randomizeBE Helmut 2012-07-06 12:51
- R-package randomizeBE d_labes 2012-07-06 09:54
- probability nearly zero! Helmut 2012-06-16 17:08
- probability nearly zero? d_labes 2012-06-16 16:11
- randomization: runs test? validation? Helmut 2012-06-16 14:00
- randomization: validation ElMaestro 2012-06-16 13:31
- randomization: runs test Helmut 2012-06-16 14:42
- randomization: runs test ElMaestro 2012-06-16 14:48
- randomization: runs test Helmut 2012-06-16 15:10
- very cool coding style ElMaestro 2012-06-16 19:12
- Better a good steal than a bad reinvention Helmut 2012-06-17 13:22
- Better a good steal than a bad reinvention ElMaestro 2012-06-17 19:58
- Sorry! Helmut 2012-06-18 13:26
- Sorry!ElMaestro 2012-06-18 15:19
- Sorry! Helmut 2012-06-18 13:26
- Better a good steal than a bad reinvention ElMaestro 2012-06-17 19:58
- Dancing with the dice d_labes 2012-06-18 15:38
- Silly's randomization 2x2 xover d_labes 2012-06-18 16:30
- Silly's randomization 2x2 xover Helmut 2012-06-18 17:14
- Clumsy code Helmut 2012-06-18 17:42
- Clumsy code ElMaestro 2012-06-18 18:01
- Speed kills Helmut 2012-06-18 18:56
- Speed kills jag009 2012-09-17 21:46
- Speed kills Helmut 2012-06-18 18:56
- Clumsy code ElMaestro 2012-06-18 18:01
- Silly's randomization 2x2 xover d_labes 2012-06-18 16:30
- Better a good steal than a bad reinvention Helmut 2012-06-17 13:22
- randomization: runs test ElMaestro 2012-06-16 14:48
- randomization: runs test Helmut 2012-06-16 14:42
- randomization: runs test? validation? d_labes 2012-06-16 13:10
- randomization: validation Helmut 2012-06-15 17:39
Ing. Helmut Schütz