Bioequivalence and Bioavailability Forum • probability nearly zero?

probability nearly zero? [Regulatives / Guidelines]

posted by d_labes – Berlin, Germany, 2012-06-16 18:11 (5113 d 02:22 ago) – Posting: # 8760
Views: 15,280

Dear Helmut!

❝ A1: A deficiency letter 20+ years ago. The randomization (by chance) was:

❝ RT TR RT TR RT TR RT TR RT TR RT TR (12 runs)

Wow! What is the probability to obtain this by chance?

BTW: My randomisation approach was always to randomize by blocks (block size 4 or if not possible by 2). Never obtained such an 'extreme' randomlist.
Random freaks may use varying block sizes chosen at random.

—
Regards,

Detlew

Complete thread:

USFDA requirement for randomization Ravi 2012-06-15 13:39 [Regulatives / Guidelines]
- randomization: validation Helmut 2012-06-15 17:39
  - randomization: runs test? validation? d_labes 2012-06-16 13:10
    - randomization: runs test? validation? Helmut 2012-06-16 14:00
      - probability nearly zero?d_labes 2012-06-16 16:11
        
        probability nearly zero! Helmut 2012-06-16 17:08
        
        R-package randomizeBE d_labes 2012-07-06 09:54
        
        R-package randomizeBE Helmut 2012-07-06 12:51
  - randomization: validation ElMaestro 2012-06-16 13:31
    - randomization: runs test Helmut 2012-06-16 14:42
      - randomization: runs test ElMaestro 2012-06-16 14:48
        
        randomization: runs test Helmut 2012-06-16 15:10
      - very cool coding style ElMaestro 2012-06-16 19:12
        
        Better a good steal than a bad reinvention Helmut 2012-06-17 13:22
        
        Better a good steal than a bad reinvention ElMaestro 2012-06-17 19:58
        
        Sorry! Helmut 2012-06-18 13:26
        
        Sorry! ElMaestro 2012-06-18 15:19
        
        Dancing with the dice d_labes 2012-06-18 15:38
        
        Silly's randomization 2x2 xover d_labes 2012-06-18 16:30
        
        Silly's randomization 2x2 xover Helmut 2012-06-18 17:14
        
        Clumsy code Helmut 2012-06-18 17:42
        
        Clumsy code ElMaestro 2012-06-18 18:01
        
        Speed kills Helmut 2012-06-18 18:56
        
        Speed kills jag009 2012-09-17 21:46