Bioequivalence and Bioavailability Forum • randomization: runs test

randomization: runs test [Regulatives / Guidelines]

posted by ElMaestro – Denmark, 2012-06-16 16:48 (4749 d 21:55 ago) – Posting: # 8757
Views: 13,227

Hi HS,

a quickie:


Scheme222=function(NSeq1, NSeq2, Seed, Sillyfactor)

{

   set.seed(Seed) 

   A=c(rep("RT", NSeq1), rep("TR",NSeq2))



   for (j in 1:Sillyfactor) 

   {

   swaps = sample(1:length(A), length(A), replace=T)

   for (i in 1:length(A))

   {

     tmp = A[i]


     A[i]=A[swaps[i]]

     A[swaps[i]]=tmp

   } ## i loop

   } ## j loop

   print(A)

}



Scheme222(12,12, 87654321, 123)

I have no idea why regulators strictly would not consider an alternating sequence random; I think they must have assumed the sequence had not been through a number-cruncher or NLYW?

—
Pass or fail!
ElMaestro

Complete thread:

USFDA requirement for randomization Ravi 2012-06-15 13:39 [Regulatives / Guidelines]
- randomization: validation Helmut 2012-06-15 17:39
  - randomization: runs test? validation? d_labes 2012-06-16 13:10
    - randomization: runs test? validation? Helmut 2012-06-16 14:00
      - probability nearly zero? d_labes 2012-06-16 16:11
        
        probability nearly zero! Helmut 2012-06-16 17:08
        
        R-package randomizeBE d_labes 2012-07-06 09:54
        
        R-package randomizeBE Helmut 2012-07-06 12:51
  - randomization: validation ElMaestro 2012-06-16 13:31
    - randomization: runs test Helmut 2012-06-16 14:42
      - randomization: runs testElMaestro 2012-06-16 14:48
        
        randomization: runs test Helmut 2012-06-16 15:10
      - very cool coding style ElMaestro 2012-06-16 19:12
        
        Better a good steal than a bad reinvention Helmut 2012-06-17 13:22
        
        Better a good steal than a bad reinvention ElMaestro 2012-06-17 19:58
        
        Sorry! Helmut 2012-06-18 13:26
        
        Sorry! ElMaestro 2012-06-18 15:19
        
        Dancing with the dice d_labes 2012-06-18 15:38
        
        Silly's randomization 2x2 xover d_labes 2012-06-18 16:30
        
        Silly's randomization 2x2 xover Helmut 2012-06-18 17:14
        
        Clumsy code Helmut 2012-06-18 17:42
        
        Clumsy code ElMaestro 2012-06-18 18:01
        
        Speed kills Helmut 2012-06-18 18:56
        
        Speed kills jag009 2012-09-17 21:46