Bioequivalence and Bioavailability Forum • randomization: runs test? validation?

randomization: runs test? validation? [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2012-06-16 16:00 (4750 d 07:21 ago) – Posting: # 8755
Views: 13,652

Dear Detlew!

❝ Q1: What is the rationale behind using the runs test :confused: .

❝ What did a randomisation based on this achieve extra compared to a randomization using lots, a hat and a NLYW dancing around it while drawing from the lots?

A1: A deficiency letter 20+ years ago. The randomization (by chance) was:
RT TR RT TR RT TR RT TR RT TR RT TR (12 runs)
We have “learned” that alternating sequences were not considered random by the authority (as would be the other extreme):
RT RT RT RT RT RT TR TR TR TR TR TR (2 runs)
Both schemes give the same significant p of 0.002465…

A2: Well…

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

USFDA requirement for randomization Ravi 2012-06-15 13:39 [Regulatives / Guidelines]
- randomization: validation Helmut 2012-06-15 17:39
  - randomization: runs test? validation? d_labes 2012-06-16 13:10
    - randomization: runs test? validation?Helmut 2012-06-16 14:00
      - probability nearly zero? d_labes 2012-06-16 16:11
        
        probability nearly zero! Helmut 2012-06-16 17:08
        
        R-package randomizeBE d_labes 2012-07-06 09:54
        
        R-package randomizeBE Helmut 2012-07-06 12:51
  - randomization: validation ElMaestro 2012-06-16 13:31
    - randomization: runs test Helmut 2012-06-16 14:42
      - randomization: runs test ElMaestro 2012-06-16 14:48
        
        randomization: runs test Helmut 2012-06-16 15:10
      - very cool coding style ElMaestro 2012-06-16 19:12
        
        Better a good steal than a bad reinvention Helmut 2012-06-17 13:22
        
        Better a good steal than a bad reinvention ElMaestro 2012-06-17 19:58
        
        Sorry! Helmut 2012-06-18 13:26
        
        Sorry! ElMaestro 2012-06-18 15:19
        
        Dancing with the dice d_labes 2012-06-18 15:38
        
        Silly's randomization 2x2 xover d_labes 2012-06-18 16:30
        
        Silly's randomization 2x2 xover Helmut 2012-06-18 17:14
        
        Clumsy code Helmut 2012-06-18 17:42
        
        Clumsy code ElMaestro 2012-06-18 18:01
        
        Speed kills Helmut 2012-06-18 18:56
        
        Speed kills jag009 2012-09-17 21:46