Bioequivalence and Bioavailability Forum • Wetware required

Wetware required [NCA / SHAM]

posted by jag009 – NJ, 2012-06-12 19:40 (4754 d 15:05 ago) – Posting: # 8714
Views: 12,434

Hi Helmut,

❝ If you want to do PK modeling you essentially have two options:

❝ • Classical 2-step: Fit subjects and calculate mean values of PK parameters. There’s a lot of literature which mean to use (harmonic means for rate constants/half lives, geometric means for volumes and clearances). This method works only if all subjects follow the same PK-model!

What if some subjects do not fit with the same PK model?

Thanks

John

Complete thread:

which time points to use for calculation of kel Samir Malhotra 2012-06-12 10:59 [NCA / SHAM]
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
  - which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
    - which time points to use for calculation of kel ElMaestro 2012-06-12 11:35
    - which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:59
      - which time points to use for calculation of kel ElMaestro 2012-06-12 12:39
        
        Wetware required Helmut 2012-06-12 15:59
        
        Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
        
        Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
        
        Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
        
        Geometric, arithmetic, median ... ? Helmut 2012-06-13 08:58
        
        Wetware required jag009 2012-06-12 17:38
        
        Wetware required Helmut 2012-06-12 19:50
        
        Wetware requiredjag009 2012-06-12 17:40
        
        Wetware required Helmut 2012-06-12 18:23
        
        Wetware required Samir Malhotra 2012-06-13 09:39
        
        Fit individuals; ignore BQLs Helmut 2012-06-13 20:33