Bioequivalence and Bioavailability Forum

Common variance! [Design Issues]

posted by Helmut  – Vienna, Austria, 2012-06-11 19:35 (4758 d 20:49 ago) – Posting: # 8686
Views: 9,952

Hi John!

❝ Agreed. I forgot to say that a larger sample size will also serve to compensate for the widening of the CIs due to potential increase in variations due to formulation performance differences. Now how much of an increase in sample size is the problem... Like you said we don't know how bad 1 or 2 out of the 3 test formulations will perform.

Everybody wants to kill two birds with one stone. What you essentially would need is a full adaptive design (adjusting for observed PEs and CVs). This is one of our member’s specialty. Acceptance? No idea.

---

P.S.: Avoid multiple blanks (a reminiscence of the age of typewriters) in your posts. They will be cut down on a single blank – so the aimed effect does not work anyway.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Curiosity: Running BE studies with more than 2 arms jag009 2012-06-11 15:01 [Design Issues] 
  • Common variance! Helmut 2012-06-11 16:23
    • Common variance! jag009 2012-06-11 17:25
      • Common variance!Helmut 2012-06-11 17:35
        • Common variance! jag009 2012-06-11 20:03
          • Common variance! ElMaestro 2012-06-11 20:34
            • Common variance! Helmut 2012-06-12 01:03
              • Common variance! ElMaestro 2012-06-12 13:22
    • Common variance! jag009 2012-06-12 19:56
      • What if I run a study with 2 references? jag009 2012-06-12 20:00
      • Common variance! Helmut 2012-06-12 20:39
        • Two References d_labes 2012-06-13 09:11
          • Two References jag009 2012-09-10 22:48
            • Two treatments only d_labes 2012-09-11 08:20
    • Common variance! jag009 2012-06-13 16:08