how to use Loo Riegelman method and deconvolution [Dissolution / BCS / IVIVC]

posted by SDavis Homepage – UK, 2012-05-18 12:32 (3211 d 13:12 ago) – Posting: # 8584
Views: 4,759

Dear Laili,

Loo-Riegelman PK model assumes two-compartment PK. I think you may need to refine your question a little as to what you need clarifying.
  1. What are you trying to achieve and with what source data?
  2. What software is your LR model implemented in?
I would, (working as I do for Pharsight :surprised:), suggest taking a look at the Numerical Deconvolution implemented in WinNonlin and Phoenix WinNonlin if you have access to these software as I've had much more comfortable results with this tool for extravascular administration. Nonetheless I understand that some people prefer the LR and WN models so these are implemented within the IVIVC module which is an additional purchase.

Phoenix (and WNL 5.x) have detailed example datasets and Guides;

C:\Program Files (x86)\Pharsight\Phoenix\application\Examples

to help step you through using these functions. And of course there is our own software forum (login required).

Simon


Edit: Extranet linked. [Helmut]

Simon
Senior Scientific Trainer, Certara™
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