SAS error in 3 way ref replicate study [RSABE / ABEL]

posted by AB – India, 2012-05-04 17:13 (4347 d 00:29 ago) – Posting: # 8514
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Dear all,

we have done a BE study in 3 way ref replicate design for FDA and ended up with the following error while running SAS code for unscaled 90% bioequivalence confidence intervals as given in "Draft Guidance on Progesterone" for parameter AUCI.

"NOTE: 20 observations are not included because of missing values.
WARNING: Did not converge."

These missing 20 observations are the ones (AUCI) which were not caculated in the respective treatment groups as the r2 values are less than 80%.

However, when we re run the data including these 20 missing AUCI (recalculated without considering the r2 criteria), there was no error.

plz suggest what is the correct way to deal with this? :confused:

Thanks in advance

Regards,
AB

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