Bioequivalence and Bioavailability Forum • Steady state calculation using WinNonlin

Steady state calculation using WinNonlin [Software]

posted by Imran – Mumbai, 2007-06-29 07:13 (6135 d 23:46 ago) – Posting: # 844
Views: 18,603
(edited by Jaime_R on 2007-06-29 10:01)

Dear HS
Thanks for ur mail and valuable suggestion on the issue. I data I want to estimate for SS study is given below.


Subject Period Trough sample      Profiling till 72.00 hrs

                  Day 1   Day-5   Day-6   Day-7  Day-7

                  0.0 hr  0.0 hr  0.0 hr  0.0 hr  1.0 hr 



  2        2      BLQ    13.344  13.689  12.272   8.427

  3        1      BLQ     2.408   2.88    3.299   2.944

  4        1      BLQ     6.068   7.562   5.267   4.734

  5        1      BLQ     4.711   6.01    6.407   5.082

  6        2      BLQ     5.594   5.134   4.733   3.691

  7        2      BLQ     4.043   5.055   3.842   3.867

  8        1      BLQ     6.104   6.033   6.144   5.251

  9        2      BLQ     7.272   8.825  10.937   6.892

 10        2      BLQ     2.671   3.53    3.655   2.744

 11        1      BLQ     2.238   6.671   3.635   3.092

 12        2      BLQ     8.961   4.591   5.078   4.127

 13        1      BLQ     9.957  11.607   8.85    7.571

 14        2      BLQ     2.596   3.972   2.756   2.696

 15        1      BLQ     5.578   5.959   4.593   3.244

 16        2      BLQ     4.135   5.602   6.656   5.397

 17        1      BLQ     3.339   3.985   2.957   3.241

 18        2      BLQ     7.984   6.268   4.776   3.843

 19        1      BLQ     5.478   5.781   5.357   4.043

 20        2      BLQ    17.672  21.912  24.53   22.566

The step I followed calculation of PK Parameters is as:
PK/PD/NCA Analysis Wizard , noncompartment modeling, select model 200, data variables, dosage regimen and selecting steady state followed by modeling, generation of PK output.

The XL file I have attached, the data processed is excluding trough sample (day1, 5, 6 and 7), should I process trough data and profiling data separately.

As u wrote in ur mail that in WinNonlin %PTF to be calculate manually, but here in my case I calculated all of the primary and secondary parameters (Excel file attached).

I have troubleshooting how the data to be presented in the WinNonline, I tried in all the possible way, but I am not sure about the output.

Primary Efficacy Parameters: Cmin, Cmax, AUC0 - 

Secondary Efficacy Parameters: Tmax, % Fluctuation

Please suggest.

Regards
Dr.Imran Khan

—
Dr.Imran Khan

Complete thread:

Steady state calculation using WinNonlin Imran 2007-06-27 06:02 [Software]
- Steady state calculation using WinNonlin Helmut 2007-06-27 11:56
  - Steady state calculation using WinNonlinImran 2007-06-29 05:13
    - Please use the Preview! Jaime_R 2007-06-29 10:29
      - Please use the Preview! Imran 2007-06-30 12:50
        
        no attachments and uploads... Jaime_R 2007-06-30 13:33
    - Steady state calculation using WinNonlin Helmut 2007-06-29 21:08
      - Steady state calculation using WinNonlin Imran 2007-08-02 13:52
        
        Steady state calculation using WinNonlin Helmut 2007-08-02 15:07
        
        Steady state calculation using WinNonlin Imran 2007-08-06 11:48
        
        Exclusion of subjects who are not in SS Helmut 2007-08-06 22:16
        
        Exclusion of subjects who are not in SS KR 2009-04-13 14:34
        Exclusion of subjects who are not in SS vixen 2020-04-27 10:10
        
        Common sense instead of statistics Helmut 2020-04-27 11:45