Bioequivalence and Bioavailability Forum • Genau Detlew!

Genau Detlew! [NCA / SHAM]

posted by SDavis – UK, 2012-04-17 18:29 (4812 d 21:08 ago) – Posting: # 8434
Views: 13,674

Agreed,
My original suggestion was essentially for the 'method 2' described in posting Posting: # 1337, when you have some profiles it was not possible/reasonable to extrapolate to AUCinf AND your Tlast is varying across subjects.

AUC to last common timepoint gives as useful secondary parameter when you suffer this unfortunate combination of (relatively) high LoQ and sub-optimal sampling schedules.

Simon

(OFF-topic if you decide to model this with NLME then the Phoenix model uses the probability that the censored observation is below the quantification limit in the likelihood function when BLQ box is checked [image]

)

—
Simon
Senior Scientific Trainer, Certara™
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Complete thread:

actual time AUC72 sciguy 2012-03-23 04:23 [NCA / SHAM]
- actual time AUC72 Dr_Dan 2012-03-23 10:25
  - actual times and AUC72 d_labes 2012-03-27 09:22
    - actual times and AUC72 sciguy 2012-04-02 20:44
      - WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 00:33
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-03 15:50
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 15:56
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-03 16:10
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 16:16
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-05 16:27
        
        pAUC72 or pAUC72+x Helmut 2012-04-05 18:25
        actual time for INPUT, nominal for the summarisation/report SDavis 2012-04-17 11:13
        
        actual time for INPUT, nominal for the summarisation/report ElMaestro 2012-04-17 11:25
        
        actual time for INPUT, nominal for the summarisation/report SDavis 2012-04-17 13:35
        
        Fishy? ElMaestro 2012-04-17 13:42
        
        ... don't think so SDavis 2012-04-17 14:09
        
        ... don't think so ElMaestro 2012-04-17 17:20
        
        AUCall and that all - Fishy? d_labes 2012-04-17 15:45
        
        Genau Detlew!SDavis 2012-04-17 16:29