>6 sources of matrix [Regulatives / Guidelines]

posted by jag009  – NJ, 2012-04-04 14:32 (3581 d 12:53 ago) – Posting: # 8382
Views: 8,324

Hi Helmut,

» » Yes the lab did reanalysis and came to the same conclusion (as per their SOP). It's just kind of strange to see value at 0 on period 1 that's all.
» OK, at least you know now that it wasn’t pure chance but at true interference.

This just popped into my head (flashback... Nightmare, whatever you called it)...

Should the lab adjust the concentration profile to remove the residual levels caused by the pre-dose concentration???? ie. using the t1/2 and determine the amount of pre-dose concentration remaining throughout the timepoints and subtract it from the respective concentrations.

I remember one lab doing this and they said it's part of their SOP...



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