WNL/PHX: pAUC72 (=hidden intra-/extrapolation) [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2012-04-03 18:16 (4825 d 02:28 ago) – Posting: # 8380
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Dear sciguy!

❝ ❝ You mean that your nominal time was 72 h and in all subjects in all periods the actual time was 72.6 h?


❝ Right, nominal time = 72 but different subjects had different actual times.


Now we are going in circles. :-D Was 72.6 h the “latest” sampling in any of the subjects? If yes and you set pAUC in PHX/WNL to 72.6 h all AUCs of subjects with tlast<72.6 will be extrapolated. I would rather set the limit for pAUC to 72 h.

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