Bioequivalence and Bioavailability Forum • WNL/PHX: pAUC72 (=hidden intra-/extrapolation)

WNL/PHX: pAUC72 (=hidden intra-/extrapolation) [NCA / SHAM]

posted by Helmut – Vienna, Austria, 2012-04-03 17:56 (4825 d 06:19 ago) – Posting: # 8378
Views: 13,879

Dear sciguy!

❝ I think setting your pAUC to 72 when your actual time is 72.6 would be the same as interpolating.

Yes.

❝ But I set my pAUC to 72.6 which would just be an AUC estimate at actual time rather than interpolation. Sorry, just wanted to clarify..

You mean that your nominal time was 72 h and in all subjects in all periods the actual time was 72.6 h?

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Complete thread:

actual time AUC72 sciguy 2012-03-23 04:23 [NCA / SHAM]
- actual time AUC72 Dr_Dan 2012-03-23 10:25
  - actual times and AUC72 d_labes 2012-03-27 09:22
    - actual times and AUC72 sciguy 2012-04-02 20:44
      - WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 00:33
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-03 15:50
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation)Helmut 2012-04-03 15:56
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-03 16:10
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 16:16
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-05 16:27
        
        pAUC72 or pAUC72+x Helmut 2012-04-05 18:25
        actual time for INPUT, nominal for the summarisation/report SDavis 2012-04-17 11:13
        
        actual time for INPUT, nominal for the summarisation/report ElMaestro 2012-04-17 11:25
        
        actual time for INPUT, nominal for the summarisation/report SDavis 2012-04-17 13:35
        
        Fishy? ElMaestro 2012-04-17 13:42
        
        ... don't think so SDavis 2012-04-17 14:09
        
        ... don't think so ElMaestro 2012-04-17 17:20
        
        AUCall and that all - Fishy? d_labes 2012-04-17 15:45
        
        Genau Detlew! SDavis 2012-04-17 16:29

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