Bioequivalence and Bioavailability Forum • WNL/PHX: pAUC72 (=hidden intra-/extrapolation)

WNL/PHX: pAUC72 (=hidden intra-/extrapolation) [NCA / SHAM]

posted by sciguy – Canada, 2012-04-03 17:50 (4825 d 02:47 ago) – Posting: # 8377
Views: 13,808

Hi Helmut!

❝ ❝ […] I set up partial areas in WNL to define the actual time rather than inter/extrapolate at 72.

❝ That’s a comfortable way of doing exactly the same. ;-) Be sure to set the method of calculation to lin-up/log-down.

I think setting your pAUC to 72 when your actual time is 72.6 would be the same as interpolating. But I set my pAUC to 72.6 which would just be an AUC estimate at actual time rather than interpolation. Sorry, just wanted to clarify..

-sciguy

Complete thread:

actual time AUC72 sciguy 2012-03-23 04:23 [NCA / SHAM]
- actual time AUC72 Dr_Dan 2012-03-23 10:25
  - actual times and AUC72 d_labes 2012-03-27 09:22
    - actual times and AUC72 sciguy 2012-04-02 20:44
      - WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 00:33
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation)sciguy 2012-04-03 15:50
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 15:56
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-03 16:10
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) Helmut 2012-04-03 16:16
        
        WNL/PHX: pAUC72 (=hidden intra-/extrapolation) sciguy 2012-04-05 16:27
        
        pAUC72 or pAUC72+x Helmut 2012-04-05 18:25
        actual time for INPUT, nominal for the summarisation/report SDavis 2012-04-17 11:13
        
        actual time for INPUT, nominal for the summarisation/report ElMaestro 2012-04-17 11:25
        
        actual time for INPUT, nominal for the summarisation/report SDavis 2012-04-17 13:35
        
        Fishy? ElMaestro 2012-04-17 13:42
        
        ... don't think so SDavis 2012-04-17 14:09
        
        ... don't think so ElMaestro 2012-04-17 17:20
        
        AUCall and that all - Fishy? d_labes 2012-04-17 15:45
        
        Genau Detlew! SDavis 2012-04-17 16:29