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Registernitpicking [PK / PD]
Dear HS,
[nitpick]
No. There is consensus that you have to analyse the data as though they (the residuals) were normal. It does not mean it is assumed that they are. Regulators, some of them at least, know that normality sometimes really, truly isn't the case but they are willing to ignore this at the evaluation stage.
[/nitpick]
Anyways, as usual I have no qualified response to any of the core stuff you have raised in this thread. Have a good day.
[nitpick]
❝ For Cmax and AUC there’s a consensus that these metrics are lognormal.
No. There is consensus that you have to analyse the data as though they (the residuals) were normal. It does not mean it is assumed that they are. Regulators, some of them at least, know that normality sometimes really, truly isn't the case but they are willing to ignore this at the evaluation stage.
[/nitpick]
Anyways, as usual I have no qualified response to any of the core stuff you have raised in this thread. Have a good day.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Empiric distributions Helmut 2012-03-21 16:18 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- nitpickingElMaestro 2012-03-21 17:32
- nitpicking Helmut 2012-03-22 16:06
- Empiric distributions martin 2012-03-21 21:16
- QQ-Plots Helmut 2012-03-22 01:17
- Transform or not transform d_labes 2012-03-22 09:31
- Transform or not transform Helmut 2012-03-22 13:27
- Transform or not transform d_labes 2012-03-22 09:31
- QQ-Plots Helmut 2012-03-22 01:17
- Empiric distributions ElMaestro 2012-03-22 18:16
- Empiric distributions Helmut 2012-03-23 01:50
- nitpickingElMaestro 2012-03-21 17:32
Ing. Helmut Schütz