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RegisterNon-superiority [Regulatives / Guidelines]
posted by Helmut 
– Vienna, Austria, 2012-03-19 17:59 (4414 d 05:49 ago) – Posting: # 8299
Views: 6,260
Dear Jaime!
Both will work.
Ouch; good question! Steven Julious (Sample Sizes for Clinical Trials, 2010) gives a method for cross-over studies (actually the other way ’round: non-inferiority) but only for normal distributed data. Have to sleep over it.
❝ […] does that require the upper one-sided 95% CL included in 125% – or […] – assessing the upper limit of the 90% CI only?
Both will work.
❝ How can we calculate the sample size?
Ouch; good question! Steven Julious (Sample Sizes for Clinical Trials, 2010) gives a method for cross-over studies (actually the other way ’round: non-inferiority) but only for normal distributed data. Have to sleep over it.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Primary and secondary parameters for SS study for EU ratnakar1811 2012-03-19 12:49 [Regulatives / Guidelines]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- MR MD studies (EMA) Helmut 2012-03-19 14:18
- Non-superiority Jaime_R 2012-03-19 16:26
- Non-superiorityHelmut 2012-03-19 16:59
- 'Non-superiority' - sample size d_labes 2012-03-20 15:48
- To err is Julious d_labes 2012-03-22 10:20
- PowerTOST 0.9-6 on CRAN Helmut 2012-03-30 14:13
- Non-superiorityHelmut 2012-03-19 16:59
- Non-superiority Jaime_R 2012-03-19 16:26
- MR MD studies (EMA) Helmut 2012-03-19 14:18
Ing. Helmut Schütz