Bioequivalence and Bioavailability Forum • and what about power?

and what about power? [BE/BA News]

posted by d_labes – Berlin, Germany, 2012-03-08 14:26 (4813 d 00:04 ago) – Posting: # 8235
Views: 22,481

Dear ElMaestro!

Very good points! I must confess I have not the slightest idea.

There is a publication out there which may be helpful:

Kem F. Phillips (!)
"Power for Testing Multiple Instances of the Two One-Sided Tests Procedure"
The International Journal of Biostatistics.
Volume 5, Issue 1, Pages 1–12.

I must further confess that I had not understood a lot of this paper.
Things like Wishart matrices are definitely beyond me.
Unfortunately Kem has only given R code for the case of two comparisions (2 TOST's).

Eventually you can make sense of it.
Thus expect some "mehl in der mehlkiste" :-)

—
Regards,

Detlew

Complete thread:

EMA: Q&A on biphasic MR products Helmut 2012-03-06 15:23 [BE/BA News]
- EMA: Q&A on biphasic MR products ElMaestro 2012-03-06 19:09
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    - EMA: Q&A on biphasic MR products ElMaestro 2012-03-07 19:20
- EMA vs. FDA d_labes 2012-03-07 10:26
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    - MPH examples d_labes 2012-03-07 16:18
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        FDA more straight? d_labes 2012-03-08 08:29
        
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        and what about power?d_labes 2012-03-08 13:26
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