Bioequivalence and Bioavailability Forum

Bad experiences… [Regulatives / Guidelines]

posted by Helmut  – Vienna, Austria, 2012-02-29 15:19 (4437 d 07:19 ago) – Posting: # 8189
Views: 8,187

Dear Detlew!

❝ That's really a Sundays exhortation ("Wort zum Sonntag"). SCNR.

Well, I’ve seen such crazy profiles in the – not so remote – past. Can you guess the country of origin? Add some scatter and .
In the log-plots an amazing mixture of convex phases and increasing values. Some self-appointed ‘experts’ extrapolated anyhow (excluding data-points they didn’t like, t_½-ranges of 0.1 – 8 h). In all these studies naïve subtraction was applied.

You can’t fix by analysis
what you bungled by design. Richard J. Light, Judith D. Singer, John B. Willett

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Pre dose concentration auditor 2012-02-28 08:59 [Regulatives / Guidelines] 
  • Pre dose concentration drgunasakaran1 2012-02-28 11:36
  • Read, Search ... d_labes 2012-02-28 12:03
    • Read, Search ... auditor 2012-02-28 12:08
      • Sorry d_labes 2012-02-28 12:49
      • Read, Search ... Helmut 2012-02-28 14:09
        • 5% Cmax rule and endogenous drugs - EMA d_labes 2012-02-28 16:40
          • My interpretation + (lenghty) example Helmut 2012-02-28 17:18
            • Well done! d_labes 2012-02-29 08:33
              • Bad experiences…Helmut 2012-02-29 14:19