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RegisterSteady state: Cmin / PTF [NCA / SHAM]
posted by Helmut 
– Vienna, Austria, 2012-02-06 15:24 (5252 d 10:22 ago) – Posting: # 8062
Views: 15,384
Hi Simon!
Nice method. Incomplete, isn’t it?
You need to sort also on
… to
Unfortunately tlast in a cross-over multiple dose study (at least in the first period) ≠ τ; the last sample is generally taken 5–10 minutes before the next administration. I would suggest using one of two methods (see here, slides 35, 48–50). Personally I prefer method (1); method (2) is PHX/WNL’s method in the calculation of AUCτ. Note that if the last sample was taken exactly at τ (f.i. in the second period), no correction will be done by both methods (i.e., the estimated Cmin = Clast and AUCτ = AUClast), since the time difference = 0 and ℯ0 = 1.
❝ The predicted Clast is extractable from the Summary table; here's a simple example with an Inner Join. See how sample time is JOINED AS Tlast, so obviously only truly appropriate where Tlast=Tau.
Nice method. Incomplete, isn’t it?
You need to sort also on
Formulation and Period, map Clast to Source Column of Worksheet 1, map Sequence to Source Column in one of the worksheets, set ☑ Inner Joint and edit cells B1 and B5 of the Sort Map from … Worksheet 1 Sorts Worksheet 2 Sorts
1 Tlast
2 Subject Subject
3 Period Period
4 Formulation Formulation
5 Time… to
Worksheet 1 Sorts Worksheet 2 Sorts
1 Tlast Time
2 Subject Subject
3 Period Period
4 Formulation FormulationUnfortunately tlast in a cross-over multiple dose study (at least in the first period) ≠ τ; the last sample is generally taken 5–10 minutes before the next administration. I would suggest using one of two methods (see here, slides 35, 48–50). Personally I prefer method (1); method (2) is PHX/WNL’s method in the calculation of AUCτ. Note that if the last sample was taken exactly at τ (f.i. in the second period), no correction will be done by both methods (i.e., the estimated Cmin = Clast and AUCτ = AUClast), since the time difference = 0 and ℯ0 = 1.
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Steady state: Cmin / PTF Helmut 2011-03-08 15:30 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Steady state: Cmin / PTF SDavis 2012-02-06 14:00
- Steady state: Cmin / PTFHelmut 2012-02-06 14:24
- Is Cmin an atavism or not? Astea 2019-02-03 22:25
- Originators | generics (Cmin | Cτ) Helmut 2019-02-04 13:18
- Down with Big Brother Astea 2019-02-04 13:51
- Down with Big Brother Helmut 2019-02-04 14:43
- thoughtcrime Astea 2019-02-04 15:13
- blackwhite Helmut 2019-02-04 15:34
- animal farm Astea 2019-02-04 15:53
- blackwhite Helmut 2019-02-04 15:34
- thoughtcrime Astea 2019-02-04 15:13
- Down with Big Brother Helmut 2019-02-04 14:43
- Down with Big Brother Astea 2019-02-04 13:51
- Originators | generics (Cmin | Cτ) Helmut 2019-02-04 13:18
- Is Cmin an atavism or not? Astea 2019-02-03 22:25
- Steady state: Cmin / PTFHelmut 2012-02-06 14:24
- Steady state: Cmin / PTF SDavis 2012-02-06 14:00
Ing. Helmut Schütz