## Steady state: Cmin / PTF [NCA / SHAM]

sorry for the late comment only just saw this;

» If you are able to estimate λz and tick [×] Intermediate Output in the Model Settings of NCA you get additionally the intercept (in log-scale) of the regression – which would allow to calculate an estimated Ĉmin value at t=τ. But this value is only given in the Core output (not available as a variable in the NCA Results)…

The predicted Clast is extractable from the Summary table; here's a simple example with an Inner Join. See how sample time is JOINED AS Tlast, so obviously only truly appropriate where Tlast=Tau.

/********* Begin Mappings ********************/ Worksheet 1 : Project.Workflow.NCA.Final Parameters Pivoted   Sort : Subject, Tlast   Source Column : Worksheet 2 : Project.Workflow.NCA.Summary Table   Sort : Subject, Time [hr ]   Source Column : Predicted [ng/mL] Sort Map : (Internal) /****************** End Mappings   ****************/

Simon
Senior Scientific Trainer, Certara™
https://www.certarauniversity.com/dashboard
https://support.certara.com/forums/