Phenotyping [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2006-03-01 13:15 (6425 d 05:22 ago) – Posting: # 80
Views: 9,362

Hi Essar!

OK, risperidone shows polymorphism, so probably you will see a wide range of plasma concentrations in your study. If you perform phenotyping, you will have an explanation for high (PM) and low concentrations (EM), but it does not...

❝ "cancel out the inter-subject variability"

You are exactly right that...

❝ inter-subject variability will be taken care of by ANOVA

So phenotyping is not necessary; it only gives you insights on the distribution of poor and extensive metabolizers in your study (which you don't need in BE assessment).

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
 Admin contact
22,771 posts in 4,777 threads, 1,627 registered users;
12 visitors (1 registered, 11 guests [including 6 identified bots]).
Forum time: 19:37 CEST (Europe/Vienna)

The real struggle is not between the right and the left
but between the party of the thoughtful
and the party of the jerks.    Jimmy Wales

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz