Phenotyping [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2006-03-01 13:15 (7071 d 21:29 ago) – Posting: # 80
Views: 11,547

Hi Essar!

OK, risperidone shows polymorphism, so probably you will see a wide range of plasma concentrations in your study. If you perform phenotyping, you will have an explanation for high (PM) and low concentrations (EM), but it does not...

❝ "cancel out the inter-subject variability"


You are exactly right that...

❝ inter-subject variability will be taken care of by ANOVA


So phenotyping is not necessary; it only gives you insights on the distribution of poor and extensive metabolizers in your study (which you don't need in BE assessment).

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