Bioequivalence and Bioavailability Forum

Intra-subject contrast (difference) [Nonparametrics]

posted by d_labes  – Berlin, Germany, 2012-01-20 13:55 (4478 d 05:52 ago) – Posting: # 7977
Views: 13,018

Dear Joshua,

❝ Could you please explain me on how to calculate the difference for the treatments for each subject when the sequence is in TRR form and then go for the non parametric analysis.

Should I really explain this?
Not many things easier than that. Take the value of tmax from the period where the subject is under treatment T(est) and subtract the mean of the two values where the subject receives R(eference).

Complete thread:

• Tmax in Partial Replicate Design Joshua 2012-01-17 06:59 [Nonparametrics] 
  • Good question! Helmut 2012-01-17 11:34
    • Good question! Joshua 2012-01-20 11:54
      • Early exposure (+scaling?) Helmut 2012-01-20 12:56
  • Tmax in Partial replicate design d_labes 2012-01-20 11:12
    • Tmax in Partial replicate design Joshua 2012-01-20 12:09
      • Intra-subject contrast (difference)d_labes 2012-01-20 12:55
        • Intra-subject contrast (difference) Joshua 2012-01-20 13:01
        • Wilcoxon for 2x2x4. "Not many things easier than that"? Astea 2023-02-14 18:44
    • Tmax in Partial replicate design mittyri 2017-01-03 23:24
      • ISC and Wilcoxon signed rank test d_labes 2017-01-04 10:21
        • ISC and Wilcoxon signed rank test in coin package mittyri 2017-01-04 14:17
          • ISC and Wilcoxon signed rank test in coin package d_labes 2017-01-04 16:09