Bioequivalence and Bioavailability Forum • THX & another request

THX & another request [Software]

posted by Helmut – Vienna, Austria, 2012-01-13 14:31 (4868 d 02:23 ago) – Posting: # 7925
Views: 7,727

Dear Shuanghe!

❝ […] for full replicate data, I have same x, boundx and pointest values as yours but different values for other parameters […]

❝ Those values were calculated based on Dlat and we should have 73 Dlat values. If I understood your post, you have 69? But 69 is the number of Ilat. Don't know if this is the reason we have different result.

Thanks a lot! You guessed right – I filtered for complete data, but should have done differently for Ilat (n=69) and Dlat (n=73). Now I could reproduce your results in Phoenix:

s2wr       0.19931360

y         -0.15879089

sWR        0.44644551

boundy    -0.12298597

critbound -0.09207634

Since sWR ≥ 0.294 apply scaled ABE:
a. -0.09207634 ≤ 0 &
b. 0.80 ≤ 1.1546 ≤ 1.25
Scaled Average BE shown (CV_WR 46.96%)

Would you be so kind and check my results for an incomplete partial replicate design as well? I removed period 3 (R) of subject 24 in data set II, and got:

pointest 1.0302521 x 0.00001265951 boundx 0.0065348721 s2wr 0.01032549 y -0.00822620 sWR 0.10161441 boundy -0.0052378774 critbound -0.0010393276
Since sWR < 0.294 apply unscaled ABE:
unscabe_pointest 1.0291 unscabe_lower 0.9775 unscabe_upper 1.0833
0.80 ≤ 0.9775 & 1.0833 ≤ 1.25
Average BE shown (CV_WR 10.33%)

Thank you in advance!

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

SAS and missing values Helmut 2012-01-06 01:47 [Software]
- SAS and missing values Shuanghe 2012-01-13 11:17
  - THX & another requestHelmut 2012-01-13 13:31
    - Congratulations for both of us :-D Shuanghe 2012-01-13 16:14
      - FDA's RSABE: Phoenix ‘validated’ against SAS Helmut 2012-01-13 16:39
        
        How to obtain CINV value in Phoenix Shuanghe 2012-01-19 11:43
        
        Import from external source Helmut 2012-01-19 14:24
        
        Thanks, it's done!! Shuanghe 2012-01-19 22:42
        
        Thanks, it's done!! Helmut 2012-01-20 00:10
- SAS and missing values JMCardot 2012-01-31 03:12