Bioequivalence and Bioavailability Forum

Liberal Conservatives [Regulatives / Guidelines]

posted by Helmut  – Vienna, Austria, 2011-11-08 23:56 (4925 d 20:15 ago) – Posting: # 7641
Views: 8,843

Dear Martin!

THX for reminding me on this paper – I remember your presentation at the Inst. for Biostat. also quite well. I overlooked this sentence in the discussion:

The total sample size in the complete data design is smaller than for the serial sampling design, with the advantage disappearing with increasing intra-subject correlation with little effect of the number of measured time points to estimate the AUC. (my emphasis)

I looked into my database and evaluated the within-subject correlation in 130+ studies and close to 3,000 subjects. I considered only studies showing BE (I can hear you shout: “Selection bias!!”). Not surprisingly correlations were quite high. Forgot to bring the data to Berlin. I will post some results ASAP.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Anticonservativism?! ElMaestro 2010-02-06 17:10 [Regulatives / Guidelines] 
  • Conservativism? Helmut 2011-11-03 21:12
    • In hindsight... ElMaestro 2011-11-03 21:43
      • In hindsight... Helmut 2011-11-04 01:56
        • In hindsight... ElMaestro 2011-11-04 08:41
        • rlnorm simulates what? d_labes 2011-11-04 09:40
          • Oops. Helmut 2011-11-04 16:05
            • Oops. ElMaestro 2011-11-04 16:22
              • Simulation of intra-subject variability d_labes 2011-11-07 11:16
                • Simulation of intra-subject variability ElMaestro 2011-11-08 11:02
            • Oops. Oops. d_labes 2011-11-25 13:54
              • Another Oops. Helmut 2011-11-25 14:23
  • Simul Ants questions d_labes 2011-11-04 15:46
    • Simul Ants questions ElMaestro 2011-11-04 16:06
    • Simul Ants questions Helmut 2011-11-04 16:09
  • Liberal Conservatives d_labes 2011-11-08 11:31
    • Liberal Conservatives martin 2011-11-08 20:50
      • Liberal ConservativesHelmut 2011-11-08 22:56
        • intra-subject correlation martin 2011-11-09 09:01
          • intra-subject correlation Helmut 2011-11-25 17:16