Bioequivalence and Bioavailability Forum

WinNonlin is lack of precision or? [Software]

posted by ElMaestro  – Denmark, 2011-11-06 15:32 (5333 d 07:36 ago) – Posting: # 7620
Views: 13,442

Dear yicaoting,

❝ But you as everyone know

except me

❝ (as WNL's usr guide pointed, Phoenix WinNonlin 6.0 guide Page 338), to convert

❝ 90% CI of LSMean(R-T) to 90% CI of GeoMean Ratio(%) (T/R), we only need a simple calculation like

❝ CI_Lower = 100 · exp(lower)

❝ CI_Upper = 100 · exp(upper)

❝ No iteration is needed, and no optimization algorithm is needed.

All software that I know of with the exception of man-made Excel sheets get the LSMEans from fitting. They are the model effects extracted from the b vector after optimsation.

Complete thread:

• WinNonlin is lack of precision or? yicaoting 2011-11-06 13:03 [Software] 
  • WinNonlin is lack of precision or? ElMaestro 2011-11-06 13:46
    • WinNonlin is lack of precision or? yicaoting 2011-11-06 14:20
      • WinNonlin is lack of precision or?ElMaestro 2011-11-06 14:32
        • WinNonlin is lack of precision or? yicaoting 2011-11-06 14:59
          • EOD? Helmut 2011-11-06 15:39
      • WinNonlin is lack of precision or? Helmut 2011-11-06 14:46
        • use an ox cleaver to kill a chicken yicaoting 2011-11-06 15:25
          • use an ox cleaver to kill a chicken Helmut 2011-11-06 15:47
  • WinNonlin’s BE wizard is known to be buggy Helmut 2011-11-06 14:14
    • WinNonlin’s BE wizard is known to be buggy yicaoting 2011-11-06 15:38
      • WinNonlin’s BE wizard is known to be buggy Helmut 2011-11-06 16:53
        • WinNonlin’s BE wizard is known to be buggy yicaoting 2011-11-06 17:12
          • WinNonlin’s power? Helmut 2011-11-06 18:29