Bioequivalence and Bioavailability Forum

rlnorm simulates what? [Regulatives / Guidelines]

posted by d_labes  – Berlin, Germany, 2011-11-04 10:40 (4930 d 09:13 ago) – Posting: # 7603
Views: 9,030

Dear Helmut!

One fundamental question:
If you simulate with rlnorm you get log-normal distributed values. Like those for AUC and Cmax in BE studies were also a log-normal distribution is assumed.

The logs of the values simulated with rlnorm will be normally distributed.
So long so good. Nothing new told here.

But now how to analyse them ?
Your code f.i. the line

❝ FullModel <- lm(y1 ~ 0 + seq1 + sub1 %in% seq1 + per1 + trt1)

or what I would do
FullModel <- lm(log(y1) ~ 0 + seq1 + sub1 %in% seq1 + per1 + trt1)

Complete thread:

• Anticonservativism?! ElMaestro 2010-02-06 17:10 [Regulatives / Guidelines] 
  • Conservativism? Helmut 2011-11-03 21:12
    • In hindsight... ElMaestro 2011-11-03 21:43
      • In hindsight... Helmut 2011-11-04 01:56
        • In hindsight... ElMaestro 2011-11-04 08:41
        • rlnorm simulates what?d_labes 2011-11-04 09:40
          • Oops. Helmut 2011-11-04 16:05
            • Oops. ElMaestro 2011-11-04 16:22
              • Simulation of intra-subject variability d_labes 2011-11-07 11:16
                • Simulation of intra-subject variability ElMaestro 2011-11-08 11:02
            • Oops. Oops. d_labes 2011-11-25 13:54
              • Another Oops. Helmut 2011-11-25 14:23
  • Simul Ants questions d_labes 2011-11-04 15:46
    • Simul Ants questions ElMaestro 2011-11-04 16:06
    • Simul Ants questions Helmut 2011-11-04 16:09
  • Liberal Conservatives d_labes 2011-11-08 11:31
    • Liberal Conservatives martin 2011-11-08 20:50
      • Liberal Conservatives Helmut 2011-11-08 22:56
        • intra-subject correlation martin 2011-11-09 09:01
          • intra-subject correlation Helmut 2011-11-25 17:16