Bioequivalence and Bioavailability Forum

In hindsight... [Regulatives / Guidelines]

posted by ElMaestro  – Denmark, 2011-11-03 22:43 (4931 d 04:36 ago) – Posting: # 7599
Views: 8,992

Hi HS,

2 comments.

1:

❝ ElMaestrosMixedModel <- lme(y1 ~ 0 + seq1 + per1 + trt1, random = ~1|sub1)

I am not sure why ElMaestro used a mixed model here; doesn't this specification just give the same as a linear model with seq1, per1, trt1, and sub1 as fixed factors ?

2:
I think we need to take degrees of freedom into consideration too. After all, the critical value of the t-dist (and thus the width of the CI which is the ultimate indicator) depends heavily on it. I think the df's differ between the two scenarios. I hope this does not lead into a discussion about how df's are calculated for a mixed model (R will not do Satterthwaite etc.), a discussion where I have absolutely nothing to contribute.


I am sorry to question my own sanity.

Complete thread:

• Anticonservativism?! ElMaestro 2010-02-06 17:10 [Regulatives / Guidelines] 
  • Conservativism? Helmut 2011-11-03 21:12
    • In hindsight...ElMaestro 2011-11-03 21:43
      • In hindsight... Helmut 2011-11-04 01:56
        • In hindsight... ElMaestro 2011-11-04 08:41
        • rlnorm simulates what? d_labes 2011-11-04 09:40
          • Oops. Helmut 2011-11-04 16:05
            • Oops. ElMaestro 2011-11-04 16:22
              • Simulation of intra-subject variability d_labes 2011-11-07 11:16
                • Simulation of intra-subject variability ElMaestro 2011-11-08 11:02
            • Oops. Oops. d_labes 2011-11-25 13:54
              • Another Oops. Helmut 2011-11-25 14:23
  • Simul Ants questions d_labes 2011-11-04 15:46
    • Simul Ants questions ElMaestro 2011-11-04 16:06
    • Simul Ants questions Helmut 2011-11-04 16:09
  • Liberal Conservatives d_labes 2011-11-08 11:31
    • Liberal Conservatives martin 2011-11-08 20:50
      • Liberal Conservatives Helmut 2011-11-08 22:56
        • intra-subject correlation martin 2011-11-09 09:01
          • intra-subject correlation Helmut 2011-11-25 17:16