Two-stage (any method) and multiplicity [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2011-10-30 18:36 (4533 d 12:34 ago) – Posting: # 7559
Views: 7,931

Dear all!

Here comes the bonus-question for hard-core-simulants: How to deal with α in a dose-proportionality study when a two-stage design is to be planned? In the past I have used a Bonferroni-correction (see this post), which is
  1. conservative and
  2. does not require independent tests (like e.g. the Šidák-correction).
Since in dose-proportionality (aside from setting up a power model) we often compare dose-adjusted responses to one dose-level (and do not perform all pairwise tests) a variant of Dunnett’s test might be suitable. Unfortunately Dunnett is only applicable for nominal scales, not for continuous ones (doses).

Opinions, ideas?

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
100 visitors (1 registered, 99 guests [including 9 identified bots]).
Forum time: 07:10 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5