Two-stage (any method) and multiplicity [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2011-10-30 18:36 (4615 d 16:21 ago) – Posting: # 7559
Views: 8,212

Dear all!

Here comes the bonus-question for hard-core-simulants: How to deal with α in a dose-proportionality study when a two-stage design is to be planned? In the past I have used a Bonferroni-correction (see this post), which is
  1. conservative and
  2. does not require independent tests (like e.g. the Šidák-correction).
Since in dose-proportionality (aside from setting up a power model) we often compare dose-adjusted responses to one dose-level (and do not perform all pairwise tests) a variant of Dunnett’s test might be suitable. Unfortunately Dunnett is only applicable for nominal scales, not for continuous ones (doses).

Opinions, ideas?

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