Bioequivalence and Bioavailability Forum

Two-stage (any method) and multiplicity [General Statistics]

posted by Helmut – Vienna, Austria, 2011-10-30 18:36 (4554 d 21:11 ago) – Posting: # 7559
Views: 8,000

Dear all!

Here comes the bonus-question for hard-core-simulants: How to deal with α in a dose-proportionality study when a two-stage design is to be planned? In the past I have used a Bonferroni-correction (see this post), which is

conservative and
does not require independent tests (like e.g. the Šidák-correction).

Since in dose-proportionality (aside from setting up a power model) we often compare dose-adjusted responses to one dose-level (and do not perform all pairwise tests) a variant of Dunnett’s test might be suitable. Unfortunately Dunnett is only applicable for nominal scales, not for continuous ones (doses).

Opinions, ideas?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

Two-stage (any method) and multiplicityHelmut 2011-10-30 17:36 [General Statistics]
- Two-stage (any method) and multiplicity ElMaestro 2011-10-30 18:26
  - Dose-dependent PK Helmut 2011-11-02 22:30
- Dunnett not for continuous scales? Really? d_labes 2011-11-01 11:11
  - Yes, yes – but another construction site Helmut 2011-11-02 22:18
    - PowerTOST help d_labes 2011-11-03 13:18
      - PowerTOST help (solved) Helmut 2011-11-03 14:28
    - intersection-union test martin 2011-11-03 22:28
      - IUT and Dunnett: code for comparison of power martin 2011-11-05 23:43

Two-stage (any method) and multiplicity [General Sta­tis­tics]

Complete thread:

Two-stage (any method) and multiplicity [General Statistics]