Bioequivalence and Bioavailability Forum • Least Square Means (LSM) for unequal sequence

Least Square Means (LSM) for unequal sequence [Regulatives / Guidelines]

posted by Pankaj Bhangale – India, 2011-10-04 16:52 (5011 d 06:19 ago) – Posting: # 7422
Views: 14,830

❝ Dear ElMaestro,

❝ ❝ 1. How to calculate LSM and SE for each Treatment? I want to manually calculate it, can anyone give me some exact equation?

❝ 1. You take the Mean of T in Seq TR and the mean of T in Seq RT. You add them and divide by two. Do the same for R. :confused:

For Example:
Suppose, n1(no. of TR Seq)=8 & n2(no. of RT Seq.)=6 (i.e. unequal sequences)

M1=Mean of T in Seq TR (n1=8) = 86.62
M2=Mean of T in Seq RT (n2=6) = 67.73

According to your formula, Combine mean is (86.62 + 67.73)/2 = 77.17 (This formula is correct when n1=n2) but here n1 & n2 are different.

I suggest Formula for Combine Mean=((n1*M1)+(n2*M2))/(n1+n2)

Mean of T in Seq TR & RT = ((8*86.62)+(6*67.73))/(8+6)=78.52

Thanks,
Best Regards,
Pankaj Bhangale

Complete thread:

Least Square Means (LSM) for unequal sequence yicaoting 2011-10-03 14:37 [Regulatives / Guidelines]
- Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 14:51
  - Least Square Means (LSM) for unequal sequence yicaoting 2011-10-03 15:28
    - Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 15:36
    - Least Square Means (LSM) for unequal sequence Helmut 2011-10-03 16:14
      - Least Square Means (LSM) for unequal sequence ElMaestro 2011-10-03 20:10
  - Least Square Means (LSM) for unequal sequencePankaj Bhangale 2011-10-04 14:52
    - Weighted Means? Helmut 2011-10-05 01:53
- LSM for unbalanced sequences -SAS- d_labes 2011-10-04 09:39
  - LSM for unbalanced sequences -SAS- yicaoting 2011-10-04 19:37
    - SE for unbalanced sequences SAS vs. WinNonlin Helmut 2011-10-05 01:01
    - LS Means mean? d_labes 2011-10-05 12:45
      - LS Means mean? ElMaestro 2011-10-05 13:23
      - PHX/WNL vs. SAS Helmut 2011-10-08 02:21
        
        PHX/WNL vs. SAS Proc Mixed d_labes 2011-10-10 15:46
        
        PHX/WNL vs. SAS Proc Mixed Helmut 2011-10-10 16:30
        
        PHX/WNL vs. SAS Proc Mixed ElMaestro 2011-10-10 19:53
        
        Real mixed effects in WNL, SAS, GLM or Mixed (1) yicaoting 2011-10-13 18:39
        Real mixed effects in WNL, SAS, GLM or Mixed (2) yicaoting 2011-10-13 18:52
        Real mixed effects in WNL, SAS, GLM or Mixed (3) yicaoting 2011-10-13 19:05
        
        Must admit I am lost ElMaestro 2011-10-14 00:02
        
        Must admit I am lost yicaoting 2011-10-14 06:30
        
        Must admit I am lost - edited ElMaestro 2011-10-14 13:23