Bioequivalence and Bioavailability Forum

EMA replicate surprise [Regulatives / Guidelines]

posted by d_labes  – Berlin, Germany, 2011-08-23 15:01 (5013 d 12:34 ago) – Posting: # 7290
Views: 8,364

Dear All!

In this posting I had observed a type III sum-of-square peculiarity in the EMA recommended code (Helmut calls it crippled ) for obtaining the intra-subject variability for the Reference formulation in replicate crossover studies.

Now I had coded (not remembering the code literally)
Proc GLM data=EMAset1;
  class period sequence subject;
  model logData =  period3 sequence1 subject(sequence)2;
  where code='R';
run; quit;
(numbers are the order in the EMA Q&A code)

The result was
                         EMA set 1

                       The GLM Procedure

Dependent Variable: logval   log(Cmax)

                                           Sum of
Source                DF         Squares     Mean Square    F Value    Pr > F

Model                 78     120.2314511       1.5414289       7.73    <.0001
Error                 71      14.1512621       0.1993136
Corrected Total      149     134.3827132


                R-Square     Coeff Var      Root MSE    logval Mean

                0.894694      5.815810      0.446445       7.676411


Source                DF       Type I SS     Mean Square    F Value    Pr > F

period                 3       1.5697687       0.5232562       2.63    0.0570
sequence               0       0.0000000        .               .       .
subject(sequence)     75     118.6616824       1.5821558       7.94    <.0001


Source                DF     Type III SS     Mean Square    F Value    Pr > F

period                 2       0.7726727       0.3863363       1.94    0.1515
sequence               0       0.0000000        .               .       .
subject(sequence)     75     118.6616824       1.5821558       7.94    <.0001


Of course I knew that the type I sum-of-squares are order dependent.
But df=0 was a great surprise for me.

Complete thread:

• EMA replicate surprised_labes 2011-08-23 13:01 [Regulatives / Guidelines] 
  • EMA replicate surprise ElMaestro 2011-08-23 13:15
    • Big bäng CV d_labes 2011-08-23 13:58
      • Big bäng CV ElMaestro 2011-08-23 15:02
        • Period DFs d_labes 2011-08-23 15:28
          • Period DFs Helmut 2011-08-23 15:36
          • Period DFs ElMaestro 2011-08-23 16:26
          • Period DFs ElMaestro 2011-08-23 16:58
            • Period DFs Helmut 2011-08-24 00:44
              • Lessons learned? d_labes 2011-08-24 11:24
                • Lessons learned? Helmut 2011-08-24 13:51
                • Lessons learned? ElMaestro 2011-08-28 21:34
            • Period DFs - EMA code literally in R d_labes 2011-08-24 10:47
              • Period DFs - EMA code literally in R ElMaestro 2011-08-24 13:04
                • call for expert’s opinions Helmut 2011-08-24 14:01
                  • call for expert’s opinions jdetlor 2011-11-01 03:05
                    • The finance sector ElMaestro 2011-11-02 09:48