Dissolution similarity [Dissolution / BCS / IVIVC]

posted by Aceto81 – Belgium, 2011-04-28 15:14 (3502 d 21:42 ago) – Posting: # 6966
Views: 17,607

Hi,

As this question comes up from time to time, I found the following reference: http://wenku.baidu.com/view/01246164783e0912a2162a08.html

I'll write a function in R, but I'm short in time for the moment.
Maybe after the weekend.

Good luck

Ace


PS: for those who want to play with the data in R:
m.ref <-
structure(list(V1 = c(42.06, 44.16, 45.63, 48.52, 50.49, 49.77
), V2 = c(59.91, 60.18, 55.77, 60.39, 61.82, 62.73), V3 = c(65.58,
67.17, 65.56, 66.51, 69.06, 69.77), V4 = c(71.81, 70.82, 70.5,
73.06, 72.85, 72.88), V5 = c(77.77, 76.11, 76.92, 78.54, 78.99,
80.18), V6 = c(85.67, 83.27, 83.91, 84.99, 86.86, 84.2), V7 = c(93.14,
88.01, 86.83, 88, 89.7, 88.88), V8 = c(94.23, 89.59, 90.12, 93.43,
90.79, 90.47)), .Names = c("V1", "V2", "V3", "V4", "V5", "V6",
"V7", "V8"), class = "data.frame", row.names = c(NA, -6L))

m.test <-
structure(list(V1 = c(19.99, 22.08, 21.93, 22.44, 25.67, 26.37
), V2 = c(36.7, 39.29, 38.54, 39.46, 42.35, 41.34), V3 = c(47.77,
49.46, 47.76, 49.72, 52.68, 51.01), V4 = c(55.08, 56.79, 55.14,
58.67, 59.71, 57.75), V5 = c(65.69, 67.22, 65.25, 69.21, 71.51,
69.44), V6 = c(81.37, 82.42, 83.49, 84.93, 86.61, 85.9), V7 = c(92.39,
89.93, 90.19, 94.12, 93.8, 94.45), V8 = c(97.1, 95.62, 95.62,
95.51, 96.7, 98.07)), .Names = c("V1", "V2", "V3", "V4", "V5",
"V6", "V7", "V8"), class = "data.frame", row.names = c(NA, -6L
))

cov(m.ref)  #Variance-covariance matrix of reference
cov(m.test) #Variance-covariance matrix of test

Complete thread:

Activity
 Admin contact
21,217 posts in 4,427 threads, 1,481 registered users;
online 22 (0 registered, 22 guests [including 17 identified bots]).
Forum time: Sunday 11:56 CET (Europe/Vienna)

Half the harm that is done in this world
Is due to people who want to feel important.    T. S. Eliot

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5