Subtleties, flaws, questions [BE/BA News]

posted by Helmut Homepage – Vienna, Austria, 2011-03-27 22:35 (4764 d 14:43 ago) – Posting: # 6818
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Dear D. Labes!

Source         DF   Type III SS   Mean Square  [...]


sequence        0    0.0000000    .            [...]

[...]


Zero degrees of freedom is not a lot.
I love SAS‘s ‘.’ - Phoenix/WinNonlin spits out ‘Not estimable’, but I can trim it to ‘.’ or even ‘0’… :-D

Open issues IMHO:
  • Outliers – which method? Model residuals or R/R ratios?
  • Obviously EMA is not interested in CVWT (Method C) at all. Since GLM throws away incomplete data (Method A), why should one go with a full replicate design? More periods, more chances of drop-outs.

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