Bioequivalence and Bioavailability Forum

SAS code: Warning [BE/BA News]

posted by d_labes  – Berlin, Germany, 2011-03-21 17:08 (5047 d 08:04 ago) – Posting: # 6790
Views: 39,150

Dear Priyanka,

❝ ... But it is showing the following error ...

❝ WARNING: ADJUST=T implies no adjustment for simultaneous inference.

as the log states this is not an ERROR:, but a WARNING:. And this warning is nonsense in the context.
You request with the option ADJUST=T confidence intervals using the t-quantile without eventually necessary multiplicity adjustments.
But multiplicity adjustment is not necessary in comparing only two possible LSMeans. It would be eventually necessary if there are more than two. Proc GLM had could that figured out, but SAS in his great wisdom had decided nevertheless to throw a warning.
Note that this warning disappears if you omit the ADJUST=T option in the LSMeans statement. Doing so Proc GLM reverts to the default method for CI calculation: confidence intervals using the t-quantile without eventually necessary multiplicity adjustments, i.e. the same as with ADJUST=T, but without a warning. What a stroke of genius .

This annoying warningo-phylistic behaviour is notorious in SAS 9.2. You can observe it in numerous instances. Check if SAS does what you intend and forget the warnings if it does.

BTW: The WARNING: has nothing to do with the data set used. You will get it also with data set I.

Complete thread:

• EMA BE-GL: Clarifications / Corrections? Helmut 2010-06-22 18:53 
  • Good news!? d_labes 2010-06-23 10:09
    • Good news!? Helmut 2010-06-23 10:11
      • Update Helmut 2011-02-05 18:48
        • Q&A published 14 March 2011 Helmut 2011-03-16 13:44
          • Q&A published 14 March 2011 ElMaestro 2011-03-16 14:20
          • Phoenix/WinNonlin 6.1.0.173 Helmut 2011-03-17 04:23
          • ANOVA party prevails d_labes 2011-03-17 11:00
            • THX! Helmut 2011-03-19 02:59
              • Outlier d_labes 2011-03-24 11:55
                • Outliers - yes, but how? Helmut 2011-03-24 15:09
                  • Questions and Ambiguities d_labes 2011-03-28 14:16
                  • Residuals and Outliers in Replicate Design Crossover Studies d_labes 2011-04-04 08:53
              • Info requested ElMag 2011-03-24 12:45
                • Confused as well... Helmut 2011-03-24 16:50
          • Q&A published 14 March 2011 Priyanka_S 2011-03-21 14:28
            • SAS code: Warningd_labes 2011-03-21 16:08
              • Copy & paste Helmut 2011-03-21 22:38
                • Subtleties, flaws, questions d_labes 2011-03-22 09:24
                  • Subtleties, flaws, questions Helmut 2011-03-27 20:35
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                      • Not estimable in the model ElMaestro 2017-03-14 11:02
                        • Not estimable in the model The user 2017-03-14 12:13
                          • Not estimable in the model ElMaestro 2017-03-14 12:41
                      • Not estimable in the model Helmut 2017-03-18 21:59
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                          • Food not the same between groups ElMaestro 2021-11-17 09:50