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RegisterMutivariate test for profile similarity [Dissolution / BCS / IVIVC]
Dear all,
in
the authors describe a test for the comparison of drug dissolution profiles which is - in the eyes of the authors - more powerful then others, like similarity factor f2, IUT test ...
This test uses the variance-covariance matrix and therefore needs the individual values of %dissolved. But in the examples given in the paper I found only means and SD for the measurement time points.
Thus I couldn't recalculate the authors values for their new delta statistic if I understand their formulas (many matrices in there
) some days.
My question: Has anybody examples of the application of this test with all necessary data? Is there any code (SAS, R or whatever) out there?
in
Saranadasa, Krishnamoorthy
"A multivariate test for similarity of two dissolution profiles"
J. Biopharm. Stat. 15: 265-278, 2005
the authors describe a test for the comparison of drug dissolution profiles which is - in the eyes of the authors - more powerful then others, like similarity factor f2, IUT test ...
This test uses the variance-covariance matrix and therefore needs the individual values of %dissolved. But in the examples given in the paper I found only means and SD for the measurement time points.
Thus I couldn't recalculate the authors values for their new delta statistic if I understand their formulas (many matrices in there
) some days.My question: Has anybody examples of the application of this test with all necessary data? Is there any code (SAS, R or whatever) out there?
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Mutivariate test for profile similarityd_labes 2011-02-23 14:47 [Dissolution / BCS / IVIVC]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Mutivariate test for profile similarity yjlee168 2011-02-24 08:50
- Mutivariate test for profile similarity d_labes 2011-02-24 15:04
- Mutivariate test for profile similarity Aceto81 2011-02-25 12:33
- Anything (?) else than f2 not acceptable in the EU? Helmut 2011-03-01 13:30
- Really not? d_labes 2011-03-01 16:07
- Really not? ElMaestro 2011-03-01 20:02
- Really not? Aceto81 2011-03-02 12:28
- Really not? d_labes 2011-03-01 16:07
- Mutivariate test for profile similarity yjlee168 2011-02-24 08:50
Ing. Helmut Schütz