Bioequivalence and Bioavailability Forum • NCA = model independent

NCA = model independent [Design Issues]

posted by NewInPK – 2011-01-31 06:47 (5624 d 19:38 ago) – Posting: # 6517
Views: 6,900

❝ If you calculate the MRT, don't forget that MRT=AUMC/AUC is only valid for extravascular data;

Dear HS,

I was searching for more information about the meaning of AUMC and have found this post. On this website (http://www.uiowa.edu/~c046138/tut-noncomp.htm) it is explained that MRT = AUMC/AUC only for instantaneous administration. I am not sure if that means "all at once" including IV and oral, as opposed to infusion and slow release, or if it means only IV bolus. If the latter is true, I wonder why is MRT calculated in WinNonlin with model 200 = extravascular?

As far as AUMC is concerned, besides the "area under the first moment curve," which doesn't help me much, the only explanation I have found so far is "a measure of the extent of distribution." Assuming I will be able to understand what it means, would it be useful to compare this parameter when comparing two different groups (for instance, different age groups)?

Thanks a lot!

Complete thread:

Regarding Time point selection of IV infusion formulation kishorpatil 2010-11-22 04:50 [Design Issues]
- Time points (infusion) Helmut 2010-11-22 14:42
  - Time points (infusion) kishorpatil 2010-11-23 10:54
    - NCA = model independent Helmut 2010-11-23 13:57
      - Details time points kishorpatil 2010-11-26 09:35
        
        Ballpark figure(s) Helmut 2010-11-26 12:59
        
        Ballpark figure(s) kishorpatil 2010-11-29 11:41
        
        Believes... Helmut 2010-11-29 13:44
        
        Believes... kishorpatil 2010-11-30 05:56
        
        Are you serious? Helmut 2010-11-30 15:38
        
        Are you serious? kishorpatil 2010-12-09 05:10
      - NCA = model independentNewInPK 2011-01-31 05:47